HCoV-OC43

Ljudski koronavirus OC43 (HCoV-OC43) pripadnik je vrste Betakoronavirus 1 koja inficira ljude i stoku. Infektirajući koronavirusom je jednolančani RNK virus u pozitivnom smislu koji ulazi u stanicu domaćina vezanjem na receptor N-acetil-9-O-acetilneuraminske kiseline.^[1]

OC43 je jedan od sedam poznatih koronavirusa koji inficiraju ljude, uključujući HCoV-229E, HCoV-NL63, HCoV-HKU1, MERS-CoV, izvorni SARS-CoV (ili SARS-CoV-1) i SARS-CoV-2. Uz ljudski koronavirus 229E, jedan je od virusa odgovornih za prehladu. Ima, kao i drugi koronavirusi iz roda Betakoronavirus, subgenus Embecovirus, dodatni kraći površinski protein u obliku šiljaka koji se naziva hemaglutinin esteraza (HE).^[2]

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↑ Li, Fang. 29. rujna 2016. Structure, Function, and Evolution of Coronavirus Spike Proteins. Annual Review of Virology. 3 (1): 237–261. doi:10.1146/annurev-virology-110615-042301. PMC 5457962. PMID 27578435. BCoV S1-NTD does not recognize galactose as galectins do. Instead, it recognizes 5-N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) (30, 43). The same sugar receptor is also recognized by human coronavirus OC43 (43, 99). OC43 and BCoV are closely related genetically, and OC43 might have resulted from zoonotic spillover of BCoV (100, 101).
↑ Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung. 24. kolovoza 2010. Coronavirus Genomics and Bioinformatics Analysis. Viruses. 2 (8): 1804–20. doi:10.3390/v2081803. PMC 3185738. PMID 21994708. In all members of Betacoronavirus subgroup A, a haemagglutinin esterase (HE) gene, which encodes a glycoprotein with neuraminate O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1).

[1] Li, Fang. 29. rujna 2016. Structure, Function, and Evolution of Coronavirus Spike Proteins. Annual Review of Virology. 3 (1): 237–261. doi:10.1146/annurev-virology-110615-042301. PMC 5457962. PMID 27578435. BCoV S1-NTD does not recognize galactose as galectins do. Instead, it recognizes 5-N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) (30, 43). The same sugar receptor is also recognized by human coronavirus OC43 (43, 99). OC43 and BCoV are closely related genetically, and OC43 might have resulted from zoonotic spillover of BCoV (100, 101).

[:03-2] Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung. 24. kolovoza 2010. Coronavirus Genomics and Bioinformatics Analysis. Viruses. 2 (8): 1804–20. doi:10.3390/v2081803. PMC 3185738. PMID 21994708. In all members of Betacoronavirus subgroup A, a haemagglutinin esterase (HE) gene, which encodes a glycoprotein with neuraminate O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1).

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