Inačica od 14. srpnja 2010. u 15:39 uredi Zmaster~hrwiki (razgovor \| doprinosi) 160 edits Nema sažetka uređivanja ← Starija izmjena		Inačica od 14. srpnja 2010. u 15:40 uredi ukloni ovu izmjenu Zmaster~hrwiki (razgovor \| doprinosi) 160 edits →‎Uzročnik Novija izmjena →
Redak 38: Četiri orthopoxvirusa mogu uzrokovati infekciju kod ljudi: variola, vaccinia, kravlje i majmunske boginje. Variola virus napada samo ljude u prirodi, iako su primati i druge životinje bile zaražene u laboratoriju. Vaccinia, kravlje i majmunske boginje mogu zaraziti i ljude i druge životinje. The lifecycle of poxviruses is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus. In order to replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses, the most important of which is a viral-associated DNA-dependent RNA polymerase. Both enveloped and unenveloped virions are infectious. The viral envelope is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin.[23] Infection with either variola major or variola minor confers immunity against the other.[4] Životni ciklus virusa boginja je kompliciran sa više infekcioznih oblika od kojih svaki ima različiti mehanizam ulaska u stanicu. Virusi boginja su jedinstveni među DNA virusima jer se repliciraju u citoplazmi a ne u jezgri. Kako bi se replicirali, virusi boginja sintetiziraju specijalizirane proteine koje ne proizvode ostali DNA virusi.

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