Crohnova bolest: razlika između inačica

{{Infokvir bolest

| latinski =

}}

[[File:Patterns of Crohn's Disease.svg|mini|250px|Najčešći dijelovi probavnog sustava zahvaćenih Chronovom bolešću.]]

 

'''Crohnova bolest''', poznata i pod imenom '''Crohnov sindrom''', '''regionalni enteritis''' i '''segmentalni ileitis''' spada u tzv. idiopatske upalne bolesti crijeva, a može zahvatiti bilo koji dio [[probavni sustav|probavnog sustava]] od [[usna šupljina|usne šupljine]] do [[anus|anusa]], te uzrokovati niz različitih [[simptom|simptoma]]. Simptomi su ponajprije abdominalna [[bol]], [[proljev]] (koji u teškim slučajevima može sadržavati krv), [[povraćanje]] (koje može biti trajno) i mršavljenje, <ref name=Baumgart>{{cite journal |doi=10.1016/S0140-6736(12)60026-9 |title=Crohn's disease |year=2012. |last1=Baumgart |first1=Daniel C |last2=Sandborn |first2=William J |journal=The Lancet |pmid=22914295 |volume=svezak 380 |issue=broj 9853 |pages=str. 1590–605}}</ref><ref>[http://www.mayoclinic.com/health/crohns-disease/DS00104/DSECTION=symptoms Crohn's Disease] Mayo Clinic, pristupljeno, studenog 2012.</ref><ref>[http://digestive.niddk.nih.gov/ddiseases/pubs/crohns/ Crohn's Disease] National Digestive Diseases Information Clearinghouse</ref> no mogu se pojaviti i simptomi izvan probavnog sustava, poput [[osip|kožnih osipa]], [[artritis|artritisa]], [[uveitis|upale oka]], umaranja i manjka koncentracije.<ref name=Baumgart/> Smatra se da je Crohnova bolest uzrokovana međudjelovanjem okolišnih, imunosnih i bakterijskih čimbenika u genetski podložnih osoba.<ref>{{cite journal |doi=10.1053/j.gastro.2011.02.046 |title=Recent Insights into the Genetics of Inflammatory Bowel Disease |year=2011. |last1=Cho |first1=Judy H. |last2=Brant |first2=Steven R. |journal=Gastroenterology |volume=svezak 140 |issue=broj 6 |pages=str. 1704.–1712. |pmid=21530736}}</ref><ref name=Bact08/><ref>{{cite journal |doi=10.2174/138945008784221170 |title=New Insights into Inflammatory Bowel Disease Pathophysiology: Paving the Way for Novel Therapeutic Targets |year=2008. |last1=Stefanelli |first1=Tommaso |last2=Malesci |first2=Alberto |last3=Repici |first3=Alessandro |last4=Vetrano |first4=Stefania |last5=Danese |first5=Silvio |journal=Current Drug Targets |volume=svezak 9 |issue=broj 5 |pages=str. 413.–418. |pmid=18473770}}</ref> Rezultat je kronična upalna bolest, pri kojoj tjelesni [[imunosni sustav]] napada probavni sustav, možda prilikom pokušaja da uništi [[antigen|antigene]] mikroba. <ref name=Bact08>{{cite journal |doi=10.1097/MCG.0b013e3181662c90 |title=Innate Immunity in Crohnʼs Disease |year=2008. |last1=Dessein |first1=Rodrigue |last2=Chamaillard |first2=Mathias |last3=Danese |first3=Silvio |journal=Journal of Clinical Gastroenterology |volume=svezak 42 |pages=str. S144–S147 |pmid=18806708}}</ref><ref name="pmid19437144">{{cite journal |pmid=19437144 |year=2010. |last1=Marks |first1=DJ |last2=Rahman |first2=FZ |last3=Sewell |first3=GW |last4=Segal |first4=AW |title=Crohn's disease: An immune deficiency state |volume=svezak 38 |issue=broj 1 |pages=str. 20.–31. |doi=10.1007/s12016-009-8133-2 |journal=Clinical reviews in allergy & immunology}}</ref> U prošlosti se Crohnova bolest pogrješno smatrala autoimunosnom bolešću, no u novije vrijeme ju stručnjaci opisuju kao bolest uslijed nedostatnosti imunosnog sustava. <ref name="pmid19437144" /><ref>{{cite journal |pmid=20594136 |year=2010. |last1=Lalande |first1=JD |last2=Behr |first2=MA |title=Mycobacteria in Crohn's disease: How innate immune deficiency may result in chronic inflammation |volume=svezak 6 |issue=broj 4 |pages=str. 633.–641. |doi=10.1586/eci.10.29 |journal=Expert review of clinical immunology}}</ref><ref>{{cite journal |first1=Jesus K |last1=Yamamoto-Furusho |first2=Joshua R |last2=Korzenik |pmid=17106921 |url=http://www.wjgnet.com/1007-9327/12/6751.asp |year=2006. |title=Crohn's disease: Innate immunodeficiency? |volume=svezak 12 |issue=broj 42 |pages=str. 6751.–6755. |journal=World Journal of Gastroenterology}}</ref><ref>http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960282-6/fulltext What's in a name? The (mis)labelling of Crohn's as an autoimmune disease</ref><ref>Defective IL-1A expression in patients with Crohn's disease is related to attenuated MAP3K4 signaling.http://www.ncbi.nlm.nih.gov/pubmed/22732089</ref><ref>Revisiting Crohn's disease as a primary immunodeficiency of macrophages http://jem.rupress.org/content/206/9/1839.full</ref>